Our study indicated that XDY might modulate the expression of miR-146b-3p, miR-146b-5p, miR-223-3p, miR-200b-3p, miR-34c-5p, miR-351-5p, miR-503-5p, miR-147-3p, miR-155-5p, miR-669a-3p, miR-7b-5p and the Mapk3, Mapk10, Fos, Stat1, and Ifnb1 mRNAs, which are associated with the ERK/JNK-AP-1 and IFN-β/STAT signalling pathways, to exert therapeutic effects on FM1-induced pneumonia. This evidence concerns the gene MAPK8 and susceptibility to pneumonia measurement.