As a component of co-inhibitory receptor signaling, via a number of B-7 checkpoint protein receptor family members, e.g., PD-1, BTLA, etc., SHP1 and/or SHP2 recruitment can serve to alter/suppress T-cell as well as select monocyte/macrophage function(s) in a number of conditions, tumor clearance, viral challenge, wound healing as well as Hem/CLP (Fallon et al. 2018). Here, PTPN11 is linked to neoplasm.