NFKB1 and hepatocellular carcinoma: Metastatic hepatocellular carcinoma cells secrete miR-1247-3p via exosomes, leading to activation of the β1-integrin–NF-κB pathway in fibroblasts and promoting a pro-inflammatory profile in these fibroblasts, which was associated with pre-metastatic niche formation and lung metastasis [111].