Metastatic hepatocellular carcinoma cells secrete exosomes containing high levels of miR-1247-3p that, when taken up by recipient fibroblasts, inhibits B4GALT3 and activates β1-integrin-NF-κB signaling. Activated fibroblasts secrete inflammatory cytokines. Here, NFKB1 is linked to hepatocellular carcinoma.