Loss of ANXA6 has been reported to destabilize the ANXA6/low-density lipoprotein receptor-related protein 1 (LRP1)/thrombospondin-1 (TSP1) complex, which leads to reduced uptake of CAF-derived exosomes by cancer cells, and a reduction in their proliferative and migratory abilities. The gene discussed is THBS1; the disease is cancer.