As an additional example of how CAF-cancer cell cross-talk can increase chemoresistance, activation of the ubiquitin-specific protease 7 (USP7)/heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) axis in gastric cancer cells exposed to paclitaxel and cisplatin increases the secretion of miR-522 in CAF-derived exosomes, leading to ferroptosis suppression in tumor cells and culminating in increased chemoresistance [161]. The gene discussed is HNRNPA1; the disease is cancer.