For instance, CAFs can recruit monocytes by secreting monocyte chemotactic protein-1 (MCP-1) and stromal cell-derived factor-1 (SDF-1); they are also able to induce transdifferentiation of M1 macrophages to M2 macrophages, which results in immunosuppression and increased cancer cell proliferation [52]. The gene discussed is CCL2; the disease is cancer.