For example, TGF-β secreted by breast cancer cells has been reported to induce a CAF phenotype in normal fibroblasts by down-regulating miR-200 and up-regulating transcription factor 12 (TCF12) and friend leukemia virus integration 1 (Fli-1) expression, thereby contributing to ECM remodeling [37]. This evidence concerns the gene FLI1 and breast carcinoma.