Still, other EV proteins have been found to promote various CAF functions, including aerobic glycolysis (integrin subunit beta 4 (ITGB4)) and CAF recruitment to metastatic tumors (Lin-28 homolog B (LIN28B)), resistance to apoptosis (WW and C2 domain containing 2 (WWC2) and survivin), increased migration or proliferation (hyaluronidase-1 (Hyal1), sphingosine-1-phosphate receptor 2 (S1PR2)), and expression of MMPs (CD147) [123,124,125,126,128,129,131,132,135]. This evidence concerns the gene ITGB4 and metastatic neoplasm.