CD40LG and Cognitive impairment: Nevertheless, the paths from the causome/protectome to the phenome (including AOPs, cognitome, and symptomatome) can be validated because it comprises genes and gene products (including CMPAase and zonulin) as well as deficits in natural IgM, which predispose to the AOPs, which are known to cause cognitive deficits and behavioral responses (see Introduction).