When NASH/fibrosis was assessed histologically and non-invasive computed tomography (CT) was used for hepatic steatosis, it is reported that three variants near PNPLA3 are associated with CT hepatic steatosis, and variants in or near LYPLAL1 and adiponutrin or PNPLA3 are associated with histologic lobular inflammation/fibrosis [77]. This evidence concerns the gene PNPLA3 and Hepatic steatosis.