Inactivation of the group 1B PLA2 (PLA2G1B), a gut digestive enzyme, suppresses diet-induced obesity, hyperglycemia, insulin resistance, and hyperlipidemia in C57BL/6 mice [66,67] and attenuates atherosclerosis and metabolic diseases in LDL receptor-deficient mice [68]. This evidence concerns the gene PLA2G1B and Insulin resistance.