When NASH/fibrosis was assessed histologically and non-invasive computed tomography (CT) was used for hepatic steatosis, it is reported that three variants near PNPLA3 are associated with CT hepatic steatosis, and variants in or near LYPLAL1 and adiponutrin or PNPLA3 are associated with histologic lobular inflammation/fibrosis [77]. Here, PNPLA3 is linked to fatty liver disease.