One of the best characterized RBPs in human cancer cells is HuR, the protein product of the embryonic lethal and abnormal vision gene ELAVL1. HuR, in contrast to its family members HuB (ELAVL2), HuC (ELAVL3) and HuD (ELAVL4), is ubiquitously expressed in human tissues and is a well-established regulator of post-transcriptional gene expression whose activity is not only controlled by abundance, but also by its subcellular localization [113,114,115]. The gene discussed is ELAVL3; the disease is cancer.