Analysis of HuR (and COX-2) in OSCC tumor tissues using immunohistochemistry demonstrated that cytoplasmic, but not nuclear HuR immunoreactivity was correlated with COX-2 expression (p < 0.025), grade (p < 0.014), lymph node (p < 0.050), and distant metastases (p < 0.025) as well as reduced survival (p < 0.023) [127]. This evidence concerns the gene ELAVL1 and neoplasm.