BIRC5 and cancer: While the precise molecular mechanism of Lin28B was not thoroughly investigated, the authors observed an increase of diverse and well-known regulators of cancer phenotypes, e.g., interleukin-6 (IL-6), high-mobility group AT-hook 2 (HMGA2), snail family transcriptional repressor 1 (SNAI1), TWIST, vascular endothelial growth factor (VEGF), and baculoviral IAP repeat containing 5 (BIRC5) [161].