MSH2 and cancer: Proband P53 with the c.182A>C, p.(Gln61Pro) variant in MSH2 gene reported cancer familiarity in both parental branches: PrC in the father and in the two paternal uncles, a not specified neoplastic disease in the third paternal aunt and in her daughter; BC in her mother, uterine cancer in the maternal grandmother, and PrC in the maternal uncle (Figure S1d).