CHEK2 LP variants, c.1136C>G, p.(Ser379Cys) and c.1169A>C, p.(Tyr390Ser), were detected in a woman with melanoma (P12) and in a Mullerian sarcoma case (P04), respectively, both referring BC and gastrointestinal cancers in relatives. This evidence concerns the gene CHEK2 and sarcoma.