It combines 232 genetic polymorphisms with protein biomarkers (PSA, fPSA, iPSA etc.)and clinical variables (age, DRE, family history etc.)When used alone for screening, S3M performed significantly better than PSA for detection of clinically significant prostate cancer (AUC 0.74 versus 0.56) [43]. The gene discussed is KLK3; the disease is Familial prostate cancer.