Comparable results have been demonstrated in studies involving TLR4, as TLR4 has been associated with endothelial and vascular inflammation [194,195] and atherosclerotic plaque formation [196], and increases macrophage, foam cell, and lipid content of plaques [196,197,198,199], hypertension [200], plaque rupture [201], and migration of vascular smooth muscle cells [202]. The gene discussed is TLR4; the disease is hypertensive disorder.