The cancer-derived exosomes could modulate (a) the matrix remodelling factors MMP-9, EFEMP1, DKK3, SPARC; (b) cytoskeletal proteins viz., “TUBB6, FEZ1, CCT6A”, (c) deubiquitin factors, (d) membrane trafficking factors, (e) apoptosis, (f) cell cycle, and (g) transcription/translation factors that contribute to the angiogenesis, metastasis, and immune evasion in cancers [83]. Here, SPARC is linked to cancer.