HIF1A and neoplasm: The authors of this study demonstrated that overexpression of TIMP-1 in tumor cells enhanced the accumulation of exo-miR-210 in a “CD63/PI3K/AKT/HIF-1-dependent signaling” and aid in the tube formation ability in HUVECs, which consequently augmented neovascularization in “A549L-derived tumor xenografts” [141].