CD8A and lung cancer: It has been shown in PDAC and lung cancer rDCs promote immunosuppression through impaired antigen presentation (i.e., lipid oxidation and inhibition of MHC-I complex expression), diminished expression of costimulatory signals (i.e., CD80 and CD86), secretion of immunosuppressive cytokines (i.e., IL-10, TGF-β) and metabolic derangement (i.e., tryptophan depletion with subsequent CD8+ T cell and NK dysfunction) [128,129,130,131,132,133,134].