We reported that tGLI1 regulates known GLI1 target genes to a similar degree as the wild-type GLI1, but gained the ability to transcriptionally activate genes not regulated by GLI1, including CD24, CD44, HPSE, TEM7, VEGF-A, VEGF-C, and VEGFR2, thus promoting cancer cell growth, migration, invasion, and angiogenesis [24,25,28,30,31]. Here, HPSE is linked to cancer.