Previously, several studies have suggested that some SNPs in LTF gene might be associated with the prevalence of metabolic abnormalities [11,12,23]; however, none of the studies evaluated the association between LTF, LRP1 and LRP2 genes polymorphisms with the prevalence of metabolically healthy or metabolically unhealthy obesity. Here, LTF is linked to obesity due to melanocortin 4 receptor deficiency.