INS and metabolic syndrome: In addition, Nakatochi et al. [25] found that the T allele in LRP2 rs2544390 polymorphism was significantly associated with a higher risk of metabolic syndrome development in Japanese male employees, whereas Sun et al. [26] noted that the T allele in LRP2 rs2544390 was significantly correlated with increased fasting insulin concentrations, HOMA-IR and the second-phase Stumvoll index.