Several pre-clinical and clinical papers have demonstrated the pleiotropic role of growth differentiation factor 15 (GDF15) [10], a stress-responsive member of the transforming growth factor β (TGF-β) cytokine superfamily, in inflammation, immune-modulation, metabolism, cancer, metastatic shifting and neo-angiogenesis, as well as for the maintenance of tissue homeostasis and cellular stress response programs after injury [11]. Here, GDF15 is linked to cancer.