MSH4 and neoplasm: The interaction of MSH4 with eIF3f (a subunit of the eIF3 complex implicated in apoptosis regulation and tumor development), for example, occurs at the region comprising the first 150 amino acids of the N-terminal domain of MSH4 (where rs5745325 is located) and has been demonstrated to foster hMSH4 stabilization and to modulate sensitivity to IR-induced DNA damage [85].