MSH3 and head and neck squamous cell carcinoma: Further, MSH3 rs26279 GG homozygosity has also been associated with decreased incidence of radiation dermatitis in breast cancer patients receiving radiotherapy [83], decreased overall survival in head and neck squamous cell carcinoma patients submitted to radiochemotherapy [81], and decreased response to platinum-based chemotherapy in advanced non-small cell lung cancer patients [84], suggesting decreased sensitivity to DNA damaging agents such as IR or platinum in GG homozygous individuals.