GNRH1 and brain neoplasm: Le Moal et al. used the national insurance database (France, 2011–2013, ICD 10 codes) to select all cases for which at least one reimbursement had been paid for gonadotrophin-releasing hormone (GnRH) agonists, and to exclude cases for which a cause of CPP had been identified (e.g., surgical intervention for brain tumors or other brain-related causes) and peripheral endocrine tumors [26].