CREB1 and Alzheimer disease: It found that it was effective for moderate to severe dementia (AD and cerebrovascular disease), but unfortunately, the number of patients was too small to be conclusive.[7] We recently showed that memory impairment in CI + Aβ rats was ameliorated by HJG administration after ischemia treatment.[8] Further, we have shown that HJG in vitro exerts a neurotrophic effect via cAMP response element binding protein (CREB) activation, and that HJG ameliorates cognitive dysfunction in dementia model rats via CREB activation.[9]