BRCA1 and Familial prostate cancer: Germline mutations in BRCA1/2 are associated with inheritable risk of breast and ovarian cancer.[12] Germline mutations of BRCA1/2 were described in 5% to 18% of ovarian cancer and in some other solid malignant tumors including breast cancer, pancreatic cancer, and less frequently in prostate cancer.[13] Few studies have reported the BRCA1/2 germline mutation in liver cancer.