Abbreviations: BG = basal ganglia, CM = cavernous malformation, CT = computed tomography, DVA = developmental venous anomaly, DWI = diffusion weighted image, IC = internal capsule, MR = magnetic resonance, MRC = Medical Research Council scale, NIHSS = National Institutes of Health Stroke Scale, SWI = susceptibility-weighted image, t-PA = tissue plasminogen activator, VBI = vertebrobasilar insufficiency. The gene discussed is PLAT; the disease is vertebrobasilar insufficiency.