It is noteworthy that the peak levels of both stimulated LH and FSH were significantly high in our female patient with MKRN3 nonsense mutation (40.4 IU/L and 18.4 IU/L, respectively), which suggested the predisposition to developing premature ovarian failure (POF) later in life.[14] Our recently published studies pointed out that CPP may serve as a prelude to hypogonadism.[15] In all published papers on MKRN3 till now, only Grandone et al[16] reported a CPP case harboring the MKRN3 mutation (Pro160Cysfs∗14) presented with the POF (premature menopause at 36 yrs). This evidence concerns the gene BRD2 and primary ovarian failure.