Herein, we report a new heterozygous MKRN3 nonsense mutation (p. Gln363∗) causing CPP in a 7-year-old Chinese girl presented with the development of breast, the onset of menstrual period, the advanced bone age (11 yrs) and the accelerated growth velocity (10 cm/yr). This evidence concerns the gene MKRN3 and central precocious puberty.