Previously, Macedo et al[13] studied in 215 Brazil CPP patients demonstrated that compared with CPP patients without MKRN3 mutations, CPP patients with MKRN3 mutations had classical features of CPP and significantly higher basal FSH levels [4.9 (4.4–10) vs 3.6 (1.0–9.8), P < 0.05]. Here, MKRN3 is linked to central precocious puberty.