Additionally, they also found the negative correlation of serum MKRN3 levels with FSH (r = -0.262, P = 0.015) and LH (r = -0.226, P = 0.037) in prepubertal girls, which further supported the major role of MKRN3 in inhibiting hypothalamic GnRH secretion during childhood.[11] What's more, both Hagen et al[11] and Lu et al[12] demonstrated that serum MKRN3 levels were significantly decreased in CPP patients in comparison with that in the non-CPP controls. This evidence concerns the gene BRD2 and central precocious puberty.