MKRN3 and central precocious puberty: Since then, more than 20 different loss-of-function genetic defects have been described, and MKRN3 mutations have been identified as the most common genetic cause of CPP.[8] Indeed, many experts suggest that MKRN3 mutations should be suspected in all familial and idiopathic CPP cases and MKRN3 gene analysis should be included in the routine clinical investigation of CPP.[2,9]