Abbreviations: Bp = biochemical progression, CP = cribriform pattern, CT = computer tomography, EAU = European Association of Urology, GS = Gleason score, mpMRI = multiparametric Magnetic Resonance Imaging, PB = prostate biopsy, PC = prostate cancer, PI-RADS = Prostate Imaging Reporting and Data System, PNI = perineural invasion, PSA = prostate-specific antigen, Rp = radiological progression, RP = radical prostatectomy, SM = surgical margins. The gene discussed is KLK3; the disease is prostate carcinoma.