Abbreviations: AD = atopic dermatitis, CCL = Chemokine (C-C motif) ligand, EASI = eczema area and severity index, IGA = Investigator's Global Assessment, IgE = immunoglobulin E, IL = interleukin, LDH = lactate dehydrogenase, NRS = numerical rating scale, POEM = patient-oriented eczema measure, SCCA2 = squamous cell carcinoma antigen-2, sIL-2R = soluble interleukin 2 receptor, Th2 = T helper type 2, TSLP = thymic stromal lymphopoietin. The gene discussed is SERPINB4; the disease is Alzheimer disease.