Examples include Notch, APP, p75NTR, Desmoglein-2, N- and E-cadherins, SORL1, LRP1, IL1 and IL6 receptors, HLA, Klotho, VEGF, IGFR, insulin receptor, and ephrins and EPH receptors to name a few [185]; AD susceptibility factors are underlined). The gene discussed is APP; the disease is Alzheimer disease.