Additionally, RAI14 acts as a regulatory protein in the retina, placenta, testes, and spermatozoa [4–6] and also participates in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated signal transduction in atherosclerosis, the innate immune signaling pathways that regulate type I interferon, the regulation of tight junctions in cells, tumor invasion phenotype, and drug sensitivity [7–9]. The gene discussed is RAI14; the disease is neoplasm.