The TMOD3/RAI14/VWF axis interacts with the cytoskeleton in prostate cancer [8], and Liu and colleagues revealed that cell migration and the invasion of melanoma was impaired by RAI14 depletion via regulating the AFAP1-AS1/miR-653-5p/RAI14 axis [15]. The gene discussed is RAI14; the disease is Familial prostate cancer.