2013). Moreover, it has been reported to down-regulate inducible nitric oxide synthase and phosphorylation of factor-κB as well as exert anti-apoptotic and anti-inflammatory effects (Lee et al. 2018). In the same line, fumarine has been reported to inhibit acetylcholinesterase activity and reduce memory impairment (Kim et al. 1999). Furthermore, ginsenoside-rh4 was found to be involved in anti-inflammatory, antioxidant, and neuronal protection (Razgonova et al. 2019; Wang et al. 2019). The gene discussed is NOS2; the disease is memory impairment.