Furthermore, the levels of reovirus proteins were similar in T3DPL/T3DTD co-infection relative to T3DPL despite high phospho-IRF3 levels, providing a first clue that IFN signalling may not play a major role in restricting the first round of reovirus replication; the role of IFN on reovirus infection will be revisited in subsequent figures. Here, IRF3 is linked to Reoviridae infectious disease.