The same rational was employed with mRNAs, where IL6R, PLXNC1, TMED10, WNK1, GRN, MXI1, TNFRSF10A all displayed negative values and thus being related toT2DM and pre-DM patients, whereas LSR and DLC1had positive values (Fig 6C) and were then related to normoglycemic controls and T1DM (Fig 5C). The gene discussed is TNFRSF10A; the disease is diabetes mellitus.