In addition, while a total of 2818 transcripts with significant p-values was found in exclusively between the pre-DM and T2DM groups, only 2 (PRR13 and SH3BP5) genes were found in common between pre-DM and T1DM and 3 (COX4I1, APEX2 and CLUAP1) were detected between T1DM and T2DM (Fig 2D). This evidence concerns the gene COX4I1 and type 2 diabetes mellitus.