APP and Alzheimer disease: The amyloid hypothesis for AD proposes that amyloid precursor protein dysmetabolism and amyloid plaques lead to neurofibrillary pathology,7 but vascular amyloid deposits are common and were initially suggested to have a mediating role.7,8 AD and cerebrovascular disease (CVD) share risk factors,9 and although a definite pathomechanistic interaction is not identified, pertinent findings strongly support a vascular component in AD.8,10, –12