In the Dominantly Inherited Alzheimer Network (DIAN) cohort of asymptomatic carriers of dominant AD genes, increased occipital WMHs occurred more than two decades before estimated time of symptom onset, coinciding with Aβ and phosphorylated tau pathology.21 Also, only parietal WMHs predicted time to incident AD dementia in a large cohort of non-demented elderly.20 On the other hand, frontal WMHs have been associated with age and cardiovascular risk, and then especially hypertension, in two recent studies.17,18. Here, MAPT is linked to Alzheimer disease.