Just as shown in Table 3, SRXN1 remained as an independent predictor of OS in HCC patients, with a HR of 1.945(95%CI:1.197‐3.159, P = .007), as well as cirrhosis (HR:1.866; 95%CI:1.126‐3.091; P = .015), HBsAg (HR:2.574; 95%CI:1.248‐5.309; P = .010), and TNM stage (HR:2.499; 95%CI:1.287‐4.855; P = .007) after adjustment confounding variables. The gene discussed is SRXN1; the disease is hepatocellular carcinoma.