The exception was represented by patient 6, in whom the expression of TRPV4 and TRPM8 channels was similar to control tissue and TRPA1, TRPV1, and TRPV2 were expressed, although at a lower level, also in the tissue used as control (probably due to an initial degree of osteoarthritis in this tissue). Here, TRPV4 is linked to osteoarthritis.