PTPRG and brain infarction: The 72 carriers of predicted loss-of-function PTPRG variants with moderate or high impact showed substantially elevated risk (Figure 7A) of a combined vascular disease phenotype encompassing the three vascular beds functionally investigated in this study (Figures 2–6): cerebral infarct (ICD-10 diagnosis code I63), angina pectoris (ICD-10 diagnosis code I20), acute myocardial infarction (ICD-10 diagnosis code I21), and acute vascular disorders of the intestine (ICD-10 diagnosis code K55.0).