POMC and Obesity: Together these results indicate (a) that current hypothalamic single-cell data and our CELLEX methodology are of a sufficient quality to detect relevant cell populations, that (b) upcoming regional atlases with increased cellular heterogeneity will drive discovery of additional relevant cell populations and cell states for complex traits, and that (c) the BMI GWAS and high-confidence obesity genes’ approaches yield comparable results with a few notable exceptions (such as the Pomc/Glipr1+ population).