Interestingly, ventromedial hypothalamic neurons have previously been implicated in control of both body fat mass and blood glucose levels; disrupted leptin signaling in Sf1-expressing ventromedial hypothalamic neurons renders mice more susceptible to diet-induced weight gain (Kim et al., 2011) and activation of ventromedial hypothalamic Sf1 neurons causes hyperglycemia (Meek et al., 2016). This evidence concerns the gene LEP and Hyperglycemia.