Moreover, four cell populations were enriched for the high-confidence obesity genes ARCME-NEURO21 (Pomc/Glipr1+), ARCME-OTHER1 (a population of non-Arc-ME neurons potentially from the retrochiasmatic area), ARCME-NEURO32 (Slc17a6/Trhr+; neurons shown to be necessary and sufficient to induce satiety [Fenselau et al., 2017]) and ARCME-NEURO28 (Qrfp+; an orexigenic neuropeptide involved in energy homeostasis [Chartrel et al., 2016]; Bonferroni threshold p<0.05/34; Figure 5b, upper panel). Here, TRHR is linked to obesity due to melanocortin 4 receptor deficiency.