Given we observed that chronic CNO-mediated hM3Dq DREADD activation of CamKIIα-positive forebrain excitatory neurons in the early postnatal window can program persistent changes in anxiety- and despair-like behavior, we next sought to ascertain whether the temporal window in which this perturbation is performed is critical to the establishment of these long-lasting behavioral changes. The gene discussed is CAMK2A; the disease is Anxiety.