TAC‐mediated myocardial fibrosis is enhanced in mice by transgenic overexpression of Nox4 (Kuroda et al, 2010), and cardiomyocyte‐specific KO is protective against myocardial fibrosis and left ventricular dysfunction (Kuroda et al, 2010; Zhao et al, 2015). Here, NOX4 is linked to Myocardial fibrosis.