AGT and diabetes mellitus: In vivo studies in mice with TAC, AngII infusion, diabetes and doxorubicin induced models of cardiomyopathy demonstrated a protective effect of pirfenidone on myocardial collagen accumulation and LV function without the early increased mortality which is seen in the acute phase with Tgfb1 KOs or TGFβRI inhibitors (Giri et al, 2004; Yamazaki et al, 2012; Wang et al, 2013).