Our results revealed that HCC patients with hypermethylation of these four genes had better OS (BCR-cg25410636, HR = 2.309, 95% CI: 1.51–3.529, P=3.2E-05; DFFA-cg20696875, HR = 2.102, 95% CI: 1.315–3.357, P=0.00078; SCUBE2-cg19000089, HR = 1.495, 95% CI: 1.048–2.134, P=0.025; TP63-cg06520450, HR = 2.00, 95% CI: 1.415–2.826, P=0.00013) (Figure 6A2,B2,C2,D2). Here, BCR is linked to hepatocellular carcinoma.