In addition, higher methylation of CDC5L-cg05671347, MERTK-cg08279316, RHOA-cg05657651 and YBX1-cg16306148, and lower methylation of BCR-cg25410636, DFFA-cg20696875, SCUBE2-cg19000089 and TP63-cg06520450, were significantly associated with better OS in HCC patients. The gene discussed is SCUBE2; the disease is hepatocellular carcinoma.