ADAM8 with a multi‐structural working domain played an important role in extracellular proteolysis, such as releasing chemokines and cytokines via ectodomain shedding (eg CD23, TNF receptor 1 and IL‐1 receptor 2) and cleaving important ECM components of the tumour stroma (eg collagen I, fibronectin and periostin).25, 26. Here, FN1 is linked to neoplasm.