Several studies have shown that ADAM8 is highly expressed in a variety of malignant tumour tissues, such as colon cancer, glioma, lung cancer, liver cancer, pancreatic cancer and gastric cancer, and promotes tumour invasion and metastasis.7, 8, 9, 10, 11, 12, 13, 14. Here, ADAM8 is linked to familial pancreatic carcinoma.