To achieve this function mainly because a variety of cytokines could upregulate or downregulate the periostin production, its production is controlled by IL4, IL-13, IL-5, TGF-CCN/CTGF (connective tissue growth factor), mechanical stretch, cancer-derived factors angiotensin II, and BMP-2 (bone morphogenetic protein 2) [16–22]. Here, CCN2 is linked to cancer.