First, periostin has played an important role in tissue remodeling and inflammation, but how this regulates globlet cells and mast cells, and the relationship between epithelial cells and perisotin still need more researches Second, epigenetic regulation in CRS has attracted more attention, which includes DNA methyl, histone and micro RNA, and epigenetic regulation also may regulate ECRS via periostin, we need to establish knockdown and/or knockout periostin in vitro models to find more underlying mechanisms. This evidence concerns the gene POSTN and congenital rubella syndrome.