Besides many previous studies, periostin has made contribution to the development and maintaince of inflammatory diseases, such as bronchial asthma, allergic rhinitis and chronic rhinosinusitis, aspirin-exacerbated respiratory diseases, allergic bronchopulmonary aspergillosis, and eosinophilic granulomatosis with polyangiitis [3, 11] via different pathways. This evidence concerns the gene POSTN and chronic rhinosinusitis.