NFKB1 and melanoma: It also might be possible that inhibiting both canonical and non-canonicalNF-κB signaling will provide additional benefit for interdicting melanomalung metastasis, winch could be tested easily by combining siRNAs in the samenanoplex since the formed particles are agnostic to the actual nucleotide sequence.In any event, these results confirm an important role for NF-κB signaling inthe progression of melanoma lung metastasis and illustrate a simple and flexiblesystemic therapeutic strategy for its local control.