Despite this, de Wolf et al. found plasma T-tau to be unchanged in Alzheimer’s disease versus cognitively normal individuals, consistent with the observations of Verberk et al. (2018), but in contrast to others (Mattsson et al., 2016; Olsson et al., 2016; Mielke et al., 2018; Pase et al., 2019). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.