Tg2576 and 3xTg mice—two well-established animal Alzheimer’s disease models (Hsiao et al., 1996; Oddo et al., 2003) which express the human APP695 with Swedish mutations (K670N-M671L), alone or in combination with MAPT P301L and PSEN1 M146V, respectively—were analysed because these Tg animals are recognized to display progressive tau-dependent, hippocampus-based synaptic and cognitive impairments (Oddo et al., 2006; Castillo-Carranza et al., 2015; Amar et al., 2017). This evidence concerns the gene PSEN1 and Cognitive impairment.