It is also worth underlining that the 12A12mAb we employed in the present study is specific for the pathological truncated tau because it selectively binds in vivo the neurotoxic Alzheimer’s disease-linked NH226-230 fragment (i.e. NH2htau) without showing any significant cross-reaction towards the intact, physiological form of protein, in line with our previous investigations (Amadoro et al., 2012). This evidence concerns the gene MAPT and Alzheimer disease.