Alternatively, the reversible nature of in vivo tau neuropathology could be restricted within strain-specific temporal window(s) because of the complex and multifactorial feature of Alzheimer’s disease pathology involving a wide range of inflammatory, oxidative, neurodegenerative causative mechanisms (Webster et al., 2014; Velazquez et al., 2018). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.