Nevertheless, the extreme N-terminal sequence of tau protein starting at D25 encompasses a not-canonical caspase(s) cleavage-site sequence (McStay et al., 2008; Kumar et al., 2014) which has been identified both in cellular (human SY5Y and rat PC12) and animal (Alzheimer’s disease11 mice) Alzheimer’s disease models (Rohn et al., 2002; Corsetti et al., 2008) and in human Alzheimer’s disease brains (Rohn et al., 2002; Amadoro et al., 2012; Quinn et al., 2018). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.