MAPT and early-onset autosomal dominant Alzheimer disease: Therefore, the discrepancy in results between two different Tg Alzheimer’s disease rodent models, each having its own characteristics, may be due to the aggressive phenotype of the human tau-overexpressing 3xTg strain, which is likely to require a more optimized immunization regimen (antibody dosage, time of treatment, timing of administration) in order to fully prevent and/or delay its robust cognition symptomatology.