In this framework, we developed a neo-epitope antibody directed against the N-terminal sequence of human tau protein DRKD(25)-QGGYTMHQDQE (Amadoro et al., 2012) which encompasses a conserved cleavage-site sequence previously identified in cellular and animal Alzheimer’s disease models (Corsetti et al., 2008) and in human Alzheimer’s disease brains (Rohn et al., 2002). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.