As a consequence, the development of selectively targeting antibodies against pathogenic tau may have a unique therapeutic advantage by leading to valuable, beneficial effects—in the absence of unwanted consequences due to the ‘loss of function’ of normal protein—in the cure of human, chronic neurodegenerative tauopathies which are sometimes expected to require long-term treatments with multiple and high-dose administrations of drugs (Kontsekova et al., 2014; Elmaleh et al., 2019). Here, MAPT is linked to tauopathy.