In this context, co-occurrence between tau and Aβ within neuronal processes and synaptic compartments has been described in Alzheimer’s disease (Hoover et al., 2010; Ittner et al., 2010; Zempel et al., 2010; Amadoro et al., 2012; Miller et al., 2014) and synaptic abnormalities occur in aging Tg2576 and 3xTg mice (Spires-Jones et al., 2007; Nisticò et al., 2012; Ameen-Ali et al., 2017). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.