In addition, an age-dependent decline in acetylcholinesterase (AChE), the enzyme responsible for acetylcholine hydrolysis (Ferreira-Vieira et al., 2016), is associated with reduced AChE in patients with Alzheimer’s disease (Hirano et al., 2012; Janeczek et al., 2018). The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.