This has further strengthened the argument favourably towards the ‘Cholinergic Hypothesis’ of Alzheimer’s disease (Terry and Buccafusco, 2003) and is supported by histological post-mortem studies showing that low-affinity p75 neurotrophin receptor (p75NTR), a marker of cholinergic basal forebrain neurons, is significantly reduced in mild cognitive impairment (Mufson et al., 2002). Here, NGFR is linked to early-onset autosomal dominant Alzheimer disease.