CHAT and early-onset autosomal dominant Alzheimer disease: In line with the ChAT reduction in L1, hippocampal AChE levels have been reported to be significantly reduced in patients with mild cognitive impairment and early Alzheimer’s disease (Rinne et al., 2003), displaying robust correlations to cognitive impairment (Shinotoh et al., 2000; Bohnen et al., 2005).