PRNP and dementia: While the dementia seen in Creutzfeldt–Jakob disease patients is likely a result of prion protein aggregation, various studies suggest that the PRNP gene is also involved in other forms of dementia, but results are inconsistent (Rujescu et al., 2003; Del Bo et al., 2006; Jeong et al., 2007; Poleggi et al., 2008; Choi et al., 2010; Golanska et al., 2013; He et al., 2013; Zhang et al., 2016).