Specifically, APOE ɛ4 carriers with elevated BP showed significant differences in risks for recurrent ICH (HR = 2.11, 95% CI 1.06–4.21, P = 0.036), dementia (HR = 1.89, 95% CI 1.05–3.41, P = 0.037) and depression (HR = 1.66, 95% CI 1.02–2.70, P = 0.044) as detailed in Fig. 2B. This evidence concerns the gene APOE and depressive symptom measurement.