APOE and hypertensive disorder: As previously described for parenchymal Aβ accumulation, hypertension severity likely leads to worsening damage to CAA-prone arterial vessels among APOE ɛ4 carriers, increasing the risk for a variety of associated clinical outcomes (de Leeuw et al., 2004; de Frias et al., 2014; Kester et al., 2014).