The APOE gene has been robustly associated with SVD and with ICH risk; indeed, APOE variants ɛ2 and ɛ4 represent by far the most potent genetic risk factors for ICH (Greenberg et al., 1995; Tzourio et al., 2008; Biffi et al., 2010b). This evidence concerns the gene APOE and snowflake vitreoretinal degeneration.