Three patients made the decision themselves to pursue enteral feeding with the full support of relatives; two presented with dysphagia unusually close to disease onset and the third, with PrP systemic amyloidosis and marked weight loss, required it as a means of additional nutritional support unrelated to dysphagia (Mead et al., 2013)—despite the different indication, this patient commenced enteral feeding at an advanced disease state consistent with other participants. Here, PRNP is linked to primary systemic amyloidosis.