NFKB1 and colorectal carcinoma: One of the critical drivers of CRC is inflammatory signaling pathways, and miR-21 as a most recognized oncogene appears to be a key modulator of several pro-oncogenic and immunomodulatory factors, such as NF-κB, and MyD88, an adapter of Toll-like receptors (TLRs) needed for NF-κB activation by TLR ligands [[34], [35], [36]].