According to the recent experiments, overexpression of miR-153 increased CRC resistance to oxaliplatin both in vitro and in vivo [70].The upregulation of miR-409-3p inhibited cell autophagic activity and enhanced the sensitivity to oxaliplatin, abrogated by the restoration of beclin-1, suggesting that miR-409-3p sensitized CRC to oxaliplatin by inhibiting beclin-1-mediated autophagy [71]. This evidence concerns the gene BECN1 and colorectal carcinoma.