For example, ferroptosis inducers (i.e., erastin, buthionine sulfoximine, and sorafenib) have been shown to improve the anticancer effects of p62 knockdown, which prevents NRF2 (nuclear factor erythroid 2-related factor 2) accumulation, in hepatocellular carcinoma cells.3 The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.