The Par3 (Bazooka)/Par6/aPKC protein kinase complex is localized at the apical cortex of the dividing neuroblast, with fate determinants such as Numb, Prospero (Pros), Staufen, and Brain tumor (Brat), and adaptor proteins such as Miranda accumulate near the basal membrane (Figure 3). Here, NUMB is linked to neoplasm.