CNGB3 and achromatopsia: So far, several disease-causing genes have been described in patients with achromatopsia.6, 7, 8, 9, 10, 11, 12, 13, 14 Mutations in patients with achromatopsia and defective cone cyclic-nucleotide-gated (CNG) channel subunits are particularly prevalent15 because mutations in CNGB3 account for 45.2% patients.16