HLA-C and graft versus host disease: Since immune tolerance is defined as antigen-specific suppression of immune reactions [32] and the known mechanisms of immune tolerance are lymphocyte anergy [26] and Treg induction [33], that allows us to state that the in vitro hyporeactivity to CBA antigens and the in vivo suppression of graft rejection and GVHD to CBA antigens accompanied by Tregs generation induced by DCs transfected with MHC antigenic determinants refers to manifestations of immune tolerance.