We also found that supplement of IFN-γ inhibited cell viability of mouse colon cancer cells CT26.WT (Figure 5(n)), implying that IFN-γ secreted from activated T cells was partly involved in the suppressed progression of colitis-associated colorectal tumorigenesis in Sirt5 KO mice. This evidence concerns the gene SIRT5 and malignant colon neoplasm.